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In a major step towards regenerative medicine of diabetes , researchers succeeded to transforme ordinary cells into insulin-producing cells in a living mouse.
This technique is called direct reprogramming which bypasses the need for stem cells that are the body's master cells which, until now, have been indispensable to efforts to custom-make tissue and organ transplants.
The researchers used three genes carried by an ordinary virus to transform mouse exocrine cells, which make up about 95 percent of the pancreas, into the scarce insulin-producing beta cells that are destroyed in type 1 or juvenile diabetes.
Dr. Douglas Melton of Harvard Medical School and Children's Hospital in Boston said that this transformation is also possible using abundant human cells such as liver, skin or fat cells.
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